A specific HPLC method for the simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite (YM-58875) in rat, dog and monkey plasma was developed and validated. The method utilized multiple-step liquid-liquid extraction followed by a reversed
✦ LIBER ✦
Simultaneous determination of YM-64227, a phosphodiesterase type 4 inhibitor, and its five metabolites in dog plasma by high-performance liquid chromatography with fluorescence detection
✍ Scribed by Daisuke Tenmizu; Yasuhisa Fukunaga; Kiyoshi Noguchi; Hidetaka Kamimura
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 143 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0269-3879
- DOI
- 10.1002/bmc.371
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## Abstract This paper describes a highly sensitive HPLC method for the simultaneous determination of 3,4‐methylenedioxymethamphetamine (MDMA), 3,4‐methylenedioxyamphetamine (MDA), amphetamine (AP) and methamphetamine (MP) in human hair samples. The amphetamines investigated were derivatized with t