A sensitive, quantitative gas chromatographic-electron capture (GC-EC) method for the determination of captopril in blood and captopril and its disulfide metabolites (collectively) in plasma was developed. After addition of an internal standard and N-ethylmaleimide to the biological samples, excess
Simultaneous determination of captopril and S-benzoyl captopril in human blood by capillary gas chromatography–mass selective detection
✍ Scribed by Mohammed Jemal; Eugene Ivashikiv; Allen I. Cohen
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 400 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1076-5174
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✦ Synopsis
Using a new table-top electron-impact mass selective detector, interfaced with a narrow bore, fused silica capillary gas chromatograph, a method has been developed for the simultaneous determination of captopril and S-benzoyl captopril. With a capillary column the two components could be chromatographically resolved, thus permitting the use of electron-impact ionization for quantitative measurements.
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