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Determination of lidocaine in human serum by capillary gas chromatography with surface ionization detection

✍ Scribed by Arimoto, Hiromi ;Shiomi, Koichi ;Fujii, Toshihiro

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
311 KB
Volume
14
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

A novel analytical method has been developed for the determination of lidocaine (2‐(diethylamino)‐N‐(2,6‐dimethyl)phenylacetamide) in human serum. After solvent extraction from serum the extract was analyzed by gas chromatography employing a van den Berg type solventless injector, a new sensitive and selective detector, the surface ionization detector, and a bonded phase flexible fused silica capillary column. The detection limit was ca. 30–50 ng/ml.

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