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Automated determination of nifedipine in human plasma by capillary gas chromatography with electron capture detection

✍ Scribed by Lutz, D. ;Ilias, E. ;Jaeger, H.

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
265 KB
Volume
9
Category
Article
ISSN
0935-6304

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✦ Synopsis

A rapid, sensitive, and reliable method for the determination of nifedipine in human plasma is described. Using a single-step solvent extraction and capillary gas chromatography combined with electron capturedetection, an assaysensitivityof 2 ng/ml is achieved routinely using 0.5 ml of plasma. Intact nifedipine is quantitated and separated from its nitroso-and nitropyridinederivatives. The suitability of the assay for pharmacokinetic studies is illustrated.

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