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Highly sensitive determination of haloperidol in human serum by capillary gas chromatography using a surface ionization detector

✍ Scribed by Nagai, Yumi ;Arimoto, Hiromi ;Fujii, Toshihiro

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
270 KB
Volume
13
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

A method has been developed for highly sensitive determination of haloperidol in human serum involving a simple extraction procedure followed by gas chromatographic separation. Target components were separated from the extracting solvents with a Van den Berg type solventless sample injector before introduction Into a DB‐1 capillary separation column. A surface ionization detector (SID), which has highly selective sensitivity for Substituted amines, was employed for quantitation using bromperidol as an internal standard. Chloroform proved to be the best extracting solvent, yielding a quantitative detection limit of 5 ng/ml (S/N = 2). Comparison of the response to target compounds obtained by the SID, FTD (flame thermionic detector), and FID (flame ionization detector) showed the SID to be superior.

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