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A rapid and highly sensitive method for the determination of glimepiride in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry: application to a pre-clinical pharmacokinetic study

✍ Scribed by Lagishetty Chakradhar; Rajareddy Kallem; Arumugam Karthik; Bala Tripura Sundari; Srirangam Ramesh; Ramesh Mullangi; Nuggehally R. Srinivas


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
202 KB
Volume
22
Category
Article
ISSN
0269-3879

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquid–liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to