Simultaneous and Interleaved Multinuclear Chemical-Shift Imaging, a Method for Concurrent, Localized Spectroscopy

✍ Scribed by O. Gonen; J. Murphyboesch; R. Srinivasan; J.N. Hu; H. Jiang; R. Stoyanova; T.R. Brown

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 789 KB
• Volume: 104
• Category: Article
• ISSN: 1064-1866
• DOI: 10.1006/jmrb.1994.1050

✦ Synopsis

A method is proposed for carrying out chemical-shift imaging simultaneously on several nuclei ( ({ }^{1} \mathrm{H}) and ({ }^{31} \mathrm{P}) in this example), using a commercial clinical NMR imager fitted with a second (\mathrm{RF}) channel and a dual-tuned birdcage coil to fit the human head. Nuclei of different (\gamma) are examined at the same field of view by exciting each nucleus successively at times proportional to (\gamma) during the same phase-encoding gradient waveform. Thus, each higher- (\gamma) nucleus is exposed to a smaller area of the gradient. Additionally, since in vivo protons typically have a shorter (T_{1}) and roughly an order of magnitude higher sensitivity than phosphorus, it is possible to interleave ' (\mathrm{H})-only acquisitions between the simultaneous ({ }^{1} \mathrm{H},{ }^{31} \mathrm{P}) observations while the lower- (\gamma) nucleus relaxes. Consequently, additional information is obtained with either higher spatial resolution or greater sensitivity (more signal averaging) without lengthening the duration of the examination.

c: 1944 Academic Press, Inc.