3D localized in vivo1H spectroscopy of human brain by using a hybrid of 1D-hadamard with 2D-chemical shift imaging

✍ Scribed by Oded Gonen; Fernando Arias-Mendoza; Gadi Goelman

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 772 KB
• Volume: 37
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910370503

✦ Synopsis

Abstract

We report acquisition of 3D image‐guided localized proton spectroscopy (^1^H‐MRS) in the human brain on a standard clinical imager. 3D coverage is achieved with a hybrid of chemical shift imaging (CSI) and transverse Hadamard spectroscopic imaging (HSI). 16 × 16 × 4 arrays of 3.5 and 1 ml voxels were obtained in 27 min. The spatially selective HSI 90° pulses incorporate naturally into a PRESS double spin‐echo sequence to subdivide the VOI into four partitions along its short axis. 2D CSI (16 × 16) is performed along the other long axes. Because the hybrid excites the spins in the entire VOI, a √N signal‐to‐noise‐ratio (SNR) gain per given examination time is realized compared with sequentially interleaving N 2D slices. A two‐fold gain in sensitivity is demonstrated in the brain for N = 4.