## Abstract Integrin‐mediated cell adhesion to proteins adsorbed onto synthetic surfaces anchors cells and triggers signals that direct cell function. In the case of fibronectin (Fn), adsorption onto substrates of varying properties alters its conformation/structure and its ability to support cell
✦ LIBER ✦
Simulations of Cell-Surface Integrin Binding to Nanoscale-Clustered Adhesion Ligands
✍ Scribed by Irvine, Darrell J.; Hue, Kerri-Ann; Mayes, Anne M.; Griffith, Linda G.
- Book ID
- 118514861
- Publisher
- Biophysical Society
- Year
- 2002
- Tongue
- English
- Weight
- 245 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0006-3495
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## Abstract We have identified the integrin subunits responsible for the initial adhesion of human osteoblast‐like cells to peptide‐modified surfaces. Biomimetic peptide surfaces containing homogenous RGD (Arg‐Gly‐Asp), homogenous FHRRIKA (Phe‐His‐Arg‐Arg‐Ile‐Lys‐Ala), and a mixed ratio of FHRRIKA: