Simplistic Expedient and Practical Synthesis of (.+-.)-α-Lipoic Acid.
✍ Scribed by Subhash P. Chavan; K. Shivsankar; K. Pasupathy
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 25 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
α-Lipoic acid / Structural analogues / Tricarbonyl(η 5 -pentadienyl)iron cations / Carbonyliron complexes / Diimide reduction Dithioester 10 was synthesized in 6 steps from tricarbonyl-also be of interest for the preparation of various labelled compounds and structural analogues. (diene)iron complex
a-Lipoic acid (thioctic acid) was oxidized in saturated solution by means of hydrogen peroxide. The NaHCO 3 resulting mixture of four structurally isomeric S-oxides (b-lipoic acids, thiosulÐnates) was characterized by NMR spectroscopy without chromatographic separation. The regio-and stereochemistry