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Enantioselective Synthesis of R-(+)-α and S-(-)-α-Lipoic Acid.

✍ Scribed by Subhash P. Chavan; Cherukupally Praveen; G. Ramakrishna; U. R. Kalkote


Publisher
John Wiley and Sons
Year
2004
Weight
17 KB
Volume
35
Category
Article
ISSN
0931-7597

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Enantioselective high-performance liquid
✍ G. Niebch; B. Büchele; J. Blome; S. Grieb; G. Brandt; P. Kampa; H. H. Raffel; M. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB

A specific plasma level assay for the enantiomers of alpha-lipoic acid is described. It makes use of liquid-liquid extraction, chemical reduction to the dithiol enantiomers, and their precolumn chiral derivatisation with o-phthalaldehyde in the presence of D-phenylalanine. The two diastereomeric der