A novel DRB gene member has recently been identified (DRB6). It defines a new supratypic group of HLA-DR alleles comprising the DRI-, DR2-, and DRw 10-carrying haplotypes. The comparison of this gene either at the nucleotide or at the protein level with other HLA-DRB genes supports its inclusion in
Simplifying genetic locus assignment of HLA-DRB genes
✍ Scribed by Göran Andersson; Leif Andersson; Dan Larhammar; Lars Rask; Sunna Sigurdardóttir
- Book ID
- 103584136
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 442 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Objective Rheumatoid arthritis (RA) has an estimated genetic contribution of 30–50%, approximately one‐third of which arises from the major histocompatibility complex on 6p21.3. Many studies have implicated alleles of DRB1 that encode a shared epitope. However, several recent studie
## Abstract ## Objective To investigate the association between variants in the __HLA–DRB1__ gene and Kashin‐Beck disease (KBD), as well as associations of selenium and iodine deficiencies with KBD in a Tibetan population. ## Methods Fourteen single‐nucleotide polymorphisms (SNPs) were genotyped
Genetic variation in the equine leucocyte antigen‐__DRB__ (__ELA‐DRB__) second exon was investigated using polymerase chain reaction (PCR) amplification, restriction fragment length polymorphism (RFLP) of PCR products (PCR‐RFLP) and deoxyribonucleic acid (DNA) sequencing. Eight distinct PCR‐RFLP pat