The HLA-DRB6 locus defines an evolutionary supratypic group within the DRB family of genes
✍ Scribed by A. Corell; J. M. Martin-Villa; P. Morales; M. D. de Juan; J. L. Vicario; J. Martínez-Laso; P. Varela; A. Arnaiz-Villena
- Book ID
- 102277732
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 289 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
A novel DRB gene member has recently been identified (DRB6). It defines a new supratypic group of HLA-DR alleles comprising the DRI-, DR2-, and DRw 10-carrying haplotypes. The comparison of this gene either at the nucleotide or at the protein level with other HLA-DRB genes supports its inclusion in the DRB gene family and not in DPB or DQB gene families. Moreover, the construction of an evolutionary gene-tree shows that this gene is probably the eldest member of the DRB gene family. Contradictory expression results do not clarify whether or not DRB6 is a pseudogene.