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Simple syntheses of hydroxamic acids and their conversion into α-hydroxy and α-amino acids

✍ Scribed by Saı̈d Boukhris; Abdelaziz Souizi

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
168 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The nucleophilic ring opening of gem-dicyanoepoxides by LiBr or Li 2 NiBr 4 , in the presence of hydroxylamine derivatives leads to new α-halo hydroxamic acids. These compounds has been used in the synthesis of αfunctionalized hydroxamic acids, α-hydroxy and α-amino acids in good yields.

📜 SIMILAR VOLUMES

Synthesis of dehydroamino acids and dide
Synthesis of dehydroamino acids and didehydrodioxopiperazines and their conversion into α-mercapto-α-amino acid derivatives
✍ Jacobus D. M. Herscheid; Henk P. H. Scholten; Marian W. Tijhuis; Harry C. J. Ott 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 600 KB

## Abstract A synthesis of α,β‐dehydroamino acid derivatives **12** is described, which is of possible general applicability and might be useful for the preparation of peptides which have such a moiety in their sequence. In addition, several didehydrodioxopiperazines (**13–17**) have been prepared.