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Simple One-Pot Synthesis of Disulfide Fragments for Use in Disulfide-Exchange Screening

โœ Scribed by Burlingame, Mark A.; Tom, Christopher T. M. B.; Renslo, Adam R.


Book ID
126876883
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
885 KB
Volume
13
Category
Article
ISSN
2156-8952

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โœ Barahman Movassagh; Mozhgan Navidi ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 161 KB

A simple, general, and highly regioselective procedure has been developed for the one-pot synthesis of b-hydroxysulfides in good yields from various styrenes and disulfides by cleavage of the S-S bond with a Zn/AlCl 3 system in aqueous acetonitrile at 80 ยฐC and in the presence of oxygen.