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Simple and efficient synthesis of tetrahydro-β-carbolines via the Pictet–Spengler reaction in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)

✍ Scribed by Wang, Li-Na; Shen, Su-Li; Qu, Jin


Book ID
126556348
Publisher
The Royal Society of Chemistry
Year
2014
Tongue
English
Weight
356 KB
Volume
4
Category
Article
ISSN
2046-2069

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Under conditions of kinetic control, the cis-diastereoselectivity of the Pictet-Spmgler ~~betwecnhyptopbanestersandeldchydescenbecontrollcdbyv~ng~si~oCIbewbrgroup; the readion pmcecda in essentially quantitative yield with most aldehydg wbea tJc&acdilldllomfonu inthepresmceofmolcallarsiev~.