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Enhancing the yield and diastereoselectivity of the Pictet-Spengler reaction: A highly efficient route to Cis-1,3-disubstituted tetrahydro-β-carbolines

✍ Scribed by Patrick D. Bailey; Madeleine H. Moore; Keith M. Morgan; David I. Smith; John M. Vernon

Book ID: 104214468
Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 182 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73247-3

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✦ Synopsis

Under conditions of kinetic control, the cis-diastereoselectivity of the Pictet-Spmgler ~~betwecnhyptopbanestersandeldchydescenbecontrollcdbyv~ng~si~oCIbewbrgroup; the readion pmcecda in essentially quantitative yield with most aldehydg wbea tJc&acdilldllomfonu inthepresmceofmolcallarsiev~.

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## Abstract For Abstract see ChemInform Abstract in Full Text.