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Silicon-mediated inactivation of semicarbazide-sensitive amine oxidase

✍ Scribed by Charles Danzin; Jean-Noël Collard; Pierrette Marchal; Daniel Schirlin

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
190 KB
Volume
5
Category
Article
ISSN
0960-894X

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✦ Synopsis

Several organosilicon amines were synthesized as potential mechanism-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO) prepared from rat aorta. 2-[Dimethyl(2-phenylethyl)silyl]methanamine, hydrochloride produced potent time-dependent inhibition of SSAO. A potential mechanism is proposed to explain SSAO inactivation by organosilicon amines.

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