𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Silicon-Mediated Inactivation of Diamine Oxidase

✍ Scribed by V.Van Dorsselaer; D. Schirlin; P. Marchal; F. Weber; C. Danzin

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
252 KB
Volume
24
Category
Article
ISSN
0045-2068

No coin nor oath required. For personal study only.

✦ Synopsis

The design, synthesis, and biologic evaluation of potential silicon-containing inhibitors of diamine oxidases (siladiaminopropane 1, silaputrescine 2, and sila analogs of cadaverine 3, 4, and 5) are described. All compounds have been prepared independently. The common feature in the reported syntheses is the way chosen to introduce the amine group relative to silicon: the Gabriel-type approach to obtaining aminomethyl-and aminopropylsilanes and the Mitsunobu-type approach to obtaining aminoethylsilanes. Among the synthesized silane diamines, compounds 1 and 3 have been found to be time-dependent inhibitors of diamine oxidases prepared from hog kidney and rat small intestine. These results extend and generalize the concept of silicon-based inactivation of amine oxidases.

πŸ“œ SIMILAR VOLUMES

Silicon-mediated inactivation of semicar
Silicon-mediated inactivation of semicarbazide-sensitive amine oxidase
✍ Charles Danzin; Jean-NoΓ«l Collard; Pierrette Marchal; Daniel Schirlin πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 190 KB

Several organosilicon amines were synthesized as potential mechanism-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO) prepared from rat aorta. 2-[Dimethyl(2-phenylethyl)silyl]methanamine, hydrochloride produced potent time-dependent inhibition of SSAO. A potential mechanism is propos

NADH-coupled spectrophotometric assay of
NADH-coupled spectrophotometric assay of diamine oxidase
✍ Silvestro DuprΓ¨; Sandro P. Solinas; Pietro Guerrieri; Giorgio Federici; Doriano πŸ“‚ Article πŸ“… 1977 πŸ› Elsevier Science 🌐 English βš– 312 KB

A simple spectrophotometric method for estimation of diamine oxidase (DAO) activity was developed, based on a coupled reaction with NADH-dependent alcohol-dehydrogenase. Cystamine, upon DA0 action, is transformed into an aminoaldehyde which reacts quickly and quantitatively with NADH in the presenc

The copper of porcine kidney diamine oxi
The copper of porcine kidney diamine oxidase.
✍ Frederick T. Greenaway; Zuwen He; John J. Hahn; Ning Xi; Yue Zou πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 104 KB