Prediction of drug disposition kinetics
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Richard H. Guy; Jonathan Hadgraft
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Article
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1984
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John Wiley and Sons
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English
โ 418 KB
The development of a physically based pharmacokinetic model for percutaneous absorption is described. The simulation includes four first-order rate constants assigned the following significance: (a) absorption across the stratum corneum; (b) diffusion through the viable tissue; (c) a retardation pro