## Abstract The main objective of this study was to determine the pharmacokinetics of the enantiomers of desbutylhalofantrine (DHF), a metabolite of halofantrine (HF), in the rat. Rats received either intravenous (2 mg/kg) or oral (7 mg/kg) (ยฑ)โDHF HCl, or (ยฑ)โHF HCl intravenously (3 mg/kg). Enanti
A general model of metabolite kinetics following intravenous and oral administration of the parent drug
โ Scribed by Michael Weiss
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 848 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Verapamil is a chiral calcium channel blocking drug which is useful clinically as the racemate in treating hypertension and arrhythmia. The published pharmacokinetic data for verapamil enantiomers in the rat model are limited. Utilizing a stereospeciยฎc highperformance liquid chromatographic (HPLC) a
## Abstract D, Lโ3โhydroxyโ3โethylโ3โphenylpropanamide (HEPP) is a synthetic drug with anticovulsant effects in a variety of seizure models. HEPP pharmacokinetics was studied after single 50 mg kg^โ1^ intravenous (IV), intraperitoneal (IP), and oral (PO) administration in male albino Wistar rats. T