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Signaling by CD40 and its mimics in B cell activation

✍ Scribed by Gail A. Bishop; Bruce S. Hostager

Book ID
111639088
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
160 KB
Volume
24
Category
Article
ISSN
0257-277X

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This study demonstrates that the engagement of CD40 results in the activation of the recently described I O B kinase (IKK) in a human B cell line. The kinase appears to reside within the cell in a cytosolic signalsome complex consisting of IKK, I O B, and an MKP-1-like molecule. While the binding of