Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1

TRAF interactions with raft-like buoyant

TRAF interactions with raft-like buoyant complexes, better than TRAF rates of degradation, differentiate signaling by CD40 and EBV latent membrane protein 1

✍ Hector Ardila-Osorio; Catherine Pioche-Durieu; Francine Puvion-Dutilleul; Bernar 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 492 KB

## Abstract The CD40 receptor and the Epstein‐Barr virus oncoprotein LMP1 are both members of the TNF‐receptor family and share several signaling mediators, including TRAF2 and TRAF3. Depending on the cell lineage and stage of maturation, LMP1 and CD40 can have synergistic, antagonist or unrelated