T cell antigen-receptor signal transduct
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Jeroen EM van Leeuwen; Lawrence E Samelson
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Article
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1999
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Elsevier Science
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English
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During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-