During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-
โฆ LIBER โฆ
Regulation of signal transduction through the T cell antigen receptor
โ Scribed by Haoran Zhao; Gary A. Koretzky
- Book ID
- 114053932
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 620 KB
- Volume
- 130
- Category
- Article
- ISSN
- 1532-6543
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Recent studies have provided insights into how the complex structure of the T-cell antigen receptor relates to its signal transduction function. Both the CD3 and zeta subunits contain functioning signaling modules that regulate the activation of tyrosine kinases and phosphorylation of cellular subst