We tested tear fluid production and lacrimal peroxidase secretion in rats without and with drug consumption with the cotton-thread tear test. Twelve frequently prescribed drugs in patients were given in recommended therapeutic and excessive doses to rats. Daily oral doses during five days of Sudafe
Side effects of drugs and tear secretion
โ Scribed by B. C. P. Polak
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 108 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0012-4486
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โฆ Synopsis
Tear secretion may be influenced by various (groups of) drugs. A survey will be given of drug-induced changes in tear secretion and their clinical consequences.
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The side effects of acetazolamide (Diamox | on lacrimation were measured in rats by means of the cotton-thread tear test. After a daily oral 1-mg dose (administered for five days), comparable to the dose used for adult humans on a drug-to-bodyweight basis, tear production remained unaffected but the