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Effect of Acetazolamide (Diamox®) on tear secretion

✍ Scribed by E. J. Agtmaal; L. Thörig; N. J. Haeringen


Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
178 KB
Volume
59
Category
Article
ISSN
0012-4486

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✦ Synopsis


The side effects of acetazolamide (Diamox | on lacrimation were measured in rats by means of the cotton-thread tear test. After a daily oral 1-mg dose (administered for five days), comparable to the dose used for adult humans on a drug-to-bodyweight basis, tear production remained unaffected but the lacrimal peroxidase secretion decreased by 60% of the baseline level. After withdrawal of acetazolmnide the peroxidase secretion returned to the baseline level.


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