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Cotton-thread tear test: an experimental study for testing drugs suspected of side effects on lacrimation

✍ Scribed by Louis Thörig; Moshe Halperin; Nicolaas J. Haeringen

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
400 KB
Volume
58
Category
Article
ISSN
0012-4486

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✦ Synopsis

We tested tear fluid production and lacrimal peroxidase secretion in rats without and with drug consumption with the cotton-thread tear test. Twelve frequently prescribed drugs in patients were given in recommended therapeutic and excessive doses to rats.

Daily oral doses during five days of Sudafed Plus ® (chlorpheniramine/pseudoephedrine combination), promethazine, atropine, timolol, aspirin, diazepam and furosemide equivalent to the doses used for adult humans on a drug-to-body-weight basis or excessive doses, resulted in about 20-60% reduction of tearing.

Changes in lacrimal peroxidase secretion were found after administration of atropine, aspirin, furosemide, indomethacine and pilocarpine. Generally, tear production and lacrimal peroxidase secretion returned to baseline levels after withdrawal of the drugs.

📜 SIMILAR VOLUMES

The fine-thread method: lacrimation test
The fine-thread method: lacrimation test for measuring ocular side-effects of drugs in the rat
✍ L. Thörig; M. Halperin; N. J. Haeringen 📂 Article 📅 1983 🏛 Springer-Verlag 🌐 English ⚖ 525 KB

Tear production was measured by means of the fine-cotton-thread method in rats. Sedation with hypnorm had no pharmacological effect on normal tear production. Daily oral administration of atropine which was comparable with the dose used for human adults on a drug-to-weight basis, resulted in a 60-pe