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Sickle cell-β0 thalassemia variant with high hemoglobin F and mild clinical course

✍ Scribed by Joseph R. Shaeffer; Joel L. Moake

Book ID
115676722
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
203 KB
Volume
61
Category
Article
ISSN
1555-7162

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📜 SIMILAR VOLUMES

Hb S/Hb Lepore with mild sickling sympto
Hb S/Hb Lepore with mild sickling symptoms: A hemoglobin variant with mostly δ-chain sequences ameliorates sickle-cell disease
✍ Fairbanks, V.F.; McCormick, D.J.; Kubik, K.S.; Rezuke, W.N.; Black, D.; Ochaney, 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 24 KB

Three cases are reported of Hb S/Hb Lepore combination with very mild sickling manifestations. The presence of a non␣-chain variant with a high proportion of ␦ chain sequences, including 22 ala, appears to ameliorate sickle-cell disease. Efforts to increase the proportion of Hb A 2 may be beneficial