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β-Globin Gene Cluster Haplotypes in a Cohort of 221 Children with Sickle Cell Anemia or Sβ0-Thalassemia and Their Association with Clinical and Hematological Features

✍ Scribed by Belisário, André Rolim; Martins, Marina Lobato; Brito, Ana Mercy Siebra; Rodrigues, Cibele Velloso; Silva, Célia Maria; Viana, Marcos Borato

Book ID: 120661464
Publisher: S. Karger AG
Year: 2010
Tongue: English
Weight: 266 KB
Volume: 124
Category: Article
ISSN: 0001-5792
DOI: 10.1159/000320271

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Effect of α-thalassemia and β-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil

✍ Figueiredo, M.S.; Kerbauy, J.; Gonçalves, M.S.; Arruda, V.R.; Saad, S.T.O.; Sona 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB 👁 1 views

To compare the features of sickle-cell anemia in Brazil with those in other locales, we studied the effects of the p-globin-like gene cluster haplotype and a-thalassemia upon the clinical and hematological features in 85 patients. The distribution of haplotypes differed from that in the United State