Short-termcis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells
โ Scribed by Stephen C. Mann; Paul A. Andrews; Stephen B. Howell
- Book ID
- 104886574
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 544 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0344-5704
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We have determined the effect of forskolin, an adenyl cy-Clare agonist, and 3-isobutyl-I-methylxanthine (IBMX), a phosphodiesterase inhibitor, on the accumulation and cytotoxicity of cisplatin (DDP) in 2008 human ovarian carcinoma cells. In DDP-sensitive 2008 cells, forskolin and IBMX caused 2. I -f
The results presented here demonstrate that a cisdiamminedichloroplatinum(II) (DDP)-resistant human ovarian-carcinoma cell line is also cross-resistant to the spermine analogue N 1 ,N 12 -bis(ethyl)spermine (BESPM). We report that C13\* cells, which are approximately 20-fold resistant to DDP, simila