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Mechanisms of resistance to cis-diamminedichloroplatinum (II) in a rat ovarian carcinoma cell line

โœ Scribed by Sekiya, S.; Oosaki, T.; Andoh, S.; Suzuki, N.; Akaboshi, M.; Takamizawa, H.


Book ID
123137483
Publisher
Elsevier Science
Year
1989
Weight
721 KB
Volume
25
Category
Article
ISSN
0277-5379

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Characteristics of five human tumor cell
โœ Beverly A. Teicher; Sylvia A. Holden; Terence S. Herman; Enrique Alvarez Sotomay ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 945 KB

In order to study the mechanisms responsible for resistance to CDDP, 5 human tumor cell lines were made resistant to CDDP by repeated in vitro exposures. After cloning it was found that the cell lines developed were between 3.3-fold and 17-fold more resistant to CDDP than the parental cell lines at