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Short-term toxicity study of allyl isothiocyanate in rats

✍ Scribed by Lewerenz, H.-J. ;Plass, R. ;Bleyl, D. W. R. ;Macholz, R.

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 308 KB
Volume: 32
Category: Article
ISSN: 0027-769X
DOI: 10.1002/food.19880320802

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✦ Synopsis

Allyl isothiocyanate (AITC) was given in doses of 0, 10, 20, or 40 mg/kg (5 days/week) by oral intubation to male rats for up to 6 weeks. The highest dosage level caused a decrease in body weight, thymus weight, blood glucose and serum globulin levels. Haematological examination revealed an increased percentage of neutrophils and a decreased percentage of lymphocytes after treatment for 2 weeks. Increased liver and adrenal weights were found in all test groups. Renal dysfunction was indicated by increased urinary aspartate amino-transferase activity, reduced urine volume and changes in the specific gravity of the urine. Histopathological changes were observed in the kidneys of animals at dosages of 20 and 40 mg/kg and in the livers of animals at the highest dosage level.

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