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Short-term toxicity studies of vanadium in rats

✍ Scribed by J. L. Domingo; J. M. Llobet; J. M. Tomas; J. Corbella

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 315 KB
Volume: 5
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550050616

No coin nor oath required. For personal study only.

✦ Synopsis

Vanadium (in the form of NaV03) was given in drinking water to groups of 10 male Sprague-Dawley rats over a period of 3 months at concentrations of 0, 5 , 10 and 50ppm. Vanadium accumulated dosedependently in the kidneys and spleen. Appearance, behaviour, food and water consumption, growth and mortality of the treated rats of all groups were not affected during the 3-month period. Histopathological investigation showed only mild though dosedependent lesions in kidneys and spleen. The plasma concentrations of urea and uric acid were increased in the highest exposure groups.

Animals and chemicals

Forty male Sprague-Dawley rats weighing 91.6 zt 10.8 g at the start of the experiment were used.

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