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Subacute oral toxicity study of benzyl isothiocyanate in rats

✍ Scribed by Lewerenz, H.-J. ;Bleyl, D. W. R. ;Plass, R.

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
462 KB
Volume
36
Category
Article
ISSN
0027-769X

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✦ Synopsis

The subacute toxicity of benzyl isothiocyanate (BITC) was investigated in male rats given oral doses of 0,50,100 and 200 mg/kg body weight/day for 4 weeks. Body weight gain and food consumption were decreased with increasing doses of BITC. Haematological changes of toxicological relevance were observed in the highest dose group. BITC administration resulted in increased serum cholesterol level in all treatment groups and decreased serum triglycerides level at 200 mg/kg. Renal dysfunction was indicated by reduced urine volume, proteinuria and enhanced urinary lactate dehydrogenase activity. BITC exposure also affected the weights of various organs and caused histological changes in the ductus choledochus, liver, ileum and mesenteric lymph nodes.

Zusammenfassung

Untersuchung der subakuten oralen Toxizitat von Benzylisothiocyanat an Ratten Die subakute Toxizitat von Benzylisothiocyanat wurde an mannlichen Ratten untersucht, denen orale Dosen von 0, 50, 100 und 200 mg/kg KM/d verabreicht wurden. Die Korpermasseentwicklung und der Futterverzehr waren mit ansteigenden BITC-Dosen verringert. Hamatologische Veranderungen von toxikologischer Relevanz wurden in der hochsten Dosisgruppe beobachtet. Die Verabreichung yon BITC bewirkte eine Erhohung des Cholesterolgehalts im Serum bei allen behandelten Gruppen und eine Verringerung des Triglyceridgehaltes im Serum bei 200 mg/kg. Nierenfunktionsstorungen BuBerten sich in vermindertem Harnvolumen, Proteinurie und erhohter Lactatdehydrogenase-Aktivitit im Harn. BITC-Exposition beeinfluBte aul3erdem die Masse verschiedener Organe und fiihrte zu histologischen Veranderungen des Ductus choledochus, der Leber, des Ileum und der mesenterialen Lymphknoten. sutivum), Indian cress (Tropaeolum mujus) [S] and melon tree (Carica papaya) [6]. There are several reports describing species differences in the metabolism of BITC [7 -91. The 0 VCH Verlagsgesellschaft mbH,

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