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Short-term regulation of the Cl−/HCO3− exchanger in immortalized SHR proximal tubular epithelial cells

✍ Scribed by Sónia Simão; Rui Pedrosa; Ulrich Hopfer; David B. Mount; Pedro A. Jose; Patrício Soares-da-Silva


Book ID
113488503
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
814 KB
Volume
75
Category
Article
ISSN
0006-2952

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H2O2 stimulates Cl−/HCO exchanger activi
✍ Sónia Simão; Pedro Gomes; Maria João Pinho; Patrício Soares-da-Silva 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 268 KB

Cl(-) /HCO (3)(-) exchanger and Na(+) /H(+) exchanger 3 are the main transporters responsible for NaCl reabsorption in kidney proximal tubules (PT). It is well accepted that membrane exchangers can be regulated by reactive oxygen species (ROS). In the kidney, ROS are known to contribute to decreases