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Oxidative stress and α1-adrenoceptor-mediated stimulation of the Cl−/HCO3− exchanger in immortalized SHR proximal tubular epithelial cells

✍ Scribed by S Simão; S Fraga; P A Jose; P Soares-da-Silva


Book ID
109838951
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
244 KB
Volume
153
Category
Article
ISSN
0007-1188

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H2O2 stimulates Cl−/HCO exchanger activi
✍ Sónia Simão; Pedro Gomes; Maria João Pinho; Patrício Soares-da-Silva 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 268 KB

Cl(-) /HCO (3)(-) exchanger and Na(+) /H(+) exchanger 3 are the main transporters responsible for NaCl reabsorption in kidney proximal tubules (PT). It is well accepted that membrane exchangers can be regulated by reactive oxygen species (ROS). In the kidney, ROS are known to contribute to decreases