Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl−/HCO3− exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR

H2O2 stimulates Cl−/HCO exchanger activi

H2O2 stimulates Cl−/HCO exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells

✍ Sónia Simão; Pedro Gomes; Maria João Pinho; Patrício Soares-da-Silva 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 268 KB

Cl(-) /HCO (3)(-) exchanger and Na(+) /H(+) exchanger 3 are the main transporters responsible for NaCl reabsorption in kidney proximal tubules (PT). It is well accepted that membrane exchangers can be regulated by reactive oxygen species (ROS). In the kidney, ROS are known to contribute to decreases