Short Synthesis of the 6,6-Spiroketal Cores of Spirofungins A and B †
✍ Scribed by Dias, Luiz C.; de Oliveira, Luciana G.
- Book ID
- 121861808
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 285 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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The 6,6-spiroacetal segment of spirofungin A, an antifungal antibiotic isolated from Streptomyces violaceusniger Tu 4113, was efficiently prepared via the coupling reaction of the Weinreb amide and the alkyne which are readily available from the common intermediate. The synthesis includes the unsymm
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