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ChemInform Abstract: Synthesis and Biological Evaluation of 6,6-Spiroketal Natural Products: Reveromycin A, B and Spirofungin A, B

✍ Scribed by Takeshi Shimizu


Publisher
John Wiley and Sons
Year
2009
Weight
15 KB
Volume
40
Category
Article
ISSN
0931-7597

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Enantioselective Total Synthesis of Reveromycin B. -The crucial steps to synthesize the title compound (VIII) include a modified Negishi coupling of alkyne (I) with iodide (II) and the Kishi-Nozaki coupling of aldehyde (IV) with iodide (V). The former coupling is more efficient and superior as compa