Short echo time proton spectroscopy of human brain using a gradient head coil

✍ Scribed by Anthony Majors; Min Xue; Thian C. Ng; Michael T. Modic

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 509 KB
• Volume: 10
• Category: Article
• ISSN: 0730-725X
• DOI: 10.1016/0730-725x(92)90017-t

✦ Synopsis

Short echo time, single voxel localized proton spectroscopy was accomplished using a stimulated echo (STEAM) sequence running on a Siemens 1.5-T system with a head coil incorporating the Z and Y gradients. Spectra from the temporal lobe, the cerebellum and mid brain were acquired from a group of normal volunteers using the following parameters: voxel size = 8 ml, TE = 22 msec, 512 signal averages and TR = 1.7 sec. STEAM spectra acquired with the small diameter gradients showed significantly fewer artifacts at short TE, allowing the observation of glutamate/glutamine, GABA, taurine, and inositol in addition to the prominent resonance of choline, creatine/phosphocreatine and N-acetylaspartate (NAA). The levels of chlorine, creatine and NAA were found to be significantly different in the three regions of the brain examined.