𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Robust analysis of short echo time 1H MRSI of human brain

✍ Scribed by X. P. Zhu; K. Young; A. Ebel; B. J. Soher; L. Kaiser; G. Matson; W. M. Weiner; N. Schuff

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
225 KB
Volume
55
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Short echo time proton MR Spectroscopic Imaging (MRSI) suffers from low signal‐to‐noise ratio (SNR), limiting accuracy to estimate metabolite intensities. A method to coherently sum spectra in a region of interest of the human brain by appropriate peak alignment was developed to yield a mean spectrum with increased SNR. Furthermore, principal component (PC) spectra were calculated to estimate the variance of the mean spectrum. The mean or alternatively the first PC (PC~1~) spectrum from the same region can be used for quantitation of peak areas of metabolites in the human brain at increased SNR. Monte Carlo simulations showed that both mean and PC~1~ spectra were more accurate in estimating regional metabolite concentrations than solutions that regress individual spectra against the tissue compositions of MRSI voxels. Back‐to‐back MRSI studies on 10 healthy volunteers showed that mean spectra markedly improved reliability of brain metabolite measurements, most notably for myo‐inositol, as compared to regression methods. Magn Reson Med, 2006. Published 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Quantitative analysis of short echo time
Quantitative analysis of short echo time 1H-MRSI of cerebral gray and white matter
✍ Mary A. McLean; Friedrich G. Woermann; Gareth J. Barker; John S. Duncan 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 372 KB

Quantitative analysis of (1)H-magnetic resonance spectroscopic imaging (MRSI) data was developed using the user-independent spectral analysis routine LCModel. Tissue segmentation was performed using statistical parametric mapping software (SPM 96), and the results were used to correct for cerebrospi

Short echo time 1H-MRSI of the human bra
Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses
✍ Tom W. J. Scheenen; Dennis W. J. Klomp; Jannie P. Wijnen; Arend Heerschap 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB 👁 1 views

## Abstract The chemical shift displacement error (CSDE) is an often‐underestimated problem in slice selection for localized proton spectroscopy at higher fields. With the proposed semi‐localized by adiabatic selective refocusing (LASER) pulse sequence, this problem is dealt with by using RF pulses

Quantitation of simulated short echo tim
Quantitation of simulated short echo time 1H human brain spectra by LCModel and AMARES
✍ Martin Kanowski; Jörn Kaufmann; Jürgen Braun; Johannes Bernarding; Claus Tempelm 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 849 KB

## Abstract LCModel and AMARES, two widely used quantitation tools for magnetic resonance spectroscopy (MRS) data, were employed to analyze simulated spectra similar to those typically obtained at short echo times (TEs) in the human brain at 1.5 T. The study focused mainly on the influence of signa

Quantitative short echo-time 1H LASER-CS
Quantitative short echo-time 1H LASER-CSI in human brain at 4 T
✍ Jennifer A. McNab; Robert Bartha 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 293 KB

A novel short echo-time 1 H chemical shift imaging (CSI) pulse sequence is presented that incorporates localization by adiabatic selective refocusing (LASER) for FOV-reduction, k-space weighted averaging and macromolecule subtraction, to obtain quantitative concentration measurements of N-acetyl-asp

Short echo time 1H MRSI of the human bra
Short echo time 1H MRSI of the human brain at 3T with adiabatic slice-selective refocusing pulses; reproducibility and variance in a dual center setting
✍ Jannie P. Wijnen; Jack J.A. van Asten; Dennis W.J. Klomp; Torill E. Sjobakk; Ing 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 356 KB 👁 1 views

## Abstract ## Purpose: To assess the reproducibility of ^1^H‐MR spectroscopic imaging (MRSI) of the human brain at 3T with volume selection by a double spin echo sequence for localization with adiabatic refocusing pulses (semi‐LASER). ## Materials and Methods: Twenty volunteers in two different