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Quantitative short echo-time 1H LASER-CSI in human brain at 4 T

✍ Scribed by Jennifer A. McNab; Robert Bartha

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
293 KB
Volume
19
Category
Article
ISSN
0952-3480

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✦ Synopsis

A novel short echo-time 1 H chemical shift imaging (CSI) pulse sequence is presented that incorporates localization by adiabatic selective refocusing (LASER) for FOV-reduction, k-space weighted averaging and macromolecule subtraction, to obtain quantitative concentration measurements of N-acetyl-aspartate, glutamate, glucose, myo-inositol, creatine and choline using a nominal voxel size of 0.56 cm 3 . A comparison of spectral quality and metabolite concentration measurements was made between LASER-CSI and LASER-single voxel spectroscopy (SVS) in a region of homogeneous parietal white matter (N ¼ 8). No significant differences were found in linewidths, signal-to-noise ratios or the effectiveness of the macromolecule subtraction between SVS and CSI. Water suppression was 45% more effective in SVS than in CSI (p < 0.05). A linear regression of all paired metabolite measurements resulted in a slope ¼ 1.01 AE 0.03 (r 2 ¼ 0.73). LASER-CSI concentration measurements of N-acetyl-aspartate, glutamate, glucose, myo-inositol, creatine and choline were in agreement (within standard deviations) with LASER-SVS measurements. LASER-CSI is, therefore, a viable and attractive option for future 1 H CSI investigations.

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