✦ LIBER ✦

Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain

✍ Scribed by Jong-Hee Hwang; Glenn D. Graham; Kevin L. Behar; Jeffry R. Alger; James W. Prichard; Dr. Douglas L. Rothman

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 777 KB
Volume: 35
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910350502

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A novel approach is presented for imaging macromolecule and metabolite signals in brain by proton magnetic resonance spectroscopic imaging. The method differentiates between metabolites and macromolecules by T~1~ weighting using an inversion pulse followed by a variable inversion recovery time before localization and spectroscopic imaging. In healthy subjects, the major macromolecule resonances at 2.05 and 0.9 ppm were mapped at a nominal spatial resolution of 1 × 1 × 1.5 cm^3^ and were demonstrated to be highly reproducible between subjects. In subacute stroke patients, a highly elevated macromolecule resonance at 1.3 ppm was mapped to infarcted brain regions, suggesting potential applications for studying pathological conditions.

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