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Short and straightforward total synthesis of Ammosamide B

✍ Scribed by Qian Wu; Xiaozhen Jiao; Liping Wang; Qiong Xiao; Xiaoyu Liu; Ping Xie

Book ID: 104097945
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 305 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.06.022

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✦ Synopsis

A simple and five steps total synthesis of Ammosamide B has been developed. The tricyclic pyrroloquinoline in Ammosamides was constructed in one step based on Doebner-Miller reaction between 1,3-diamine-4,6-dinitrobenzene 8 and dimethyl-2-oxo glutaconate 9.

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