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Short and convenient synthesis of triethoxy-[2H]methane and ethoxy-[2H]methylene malononitrile

✍ Scribed by Georg Uray; Claude Celotto

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
160 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

Triethoxy-deuteriomethane

i s s y n t h e s i z e d s i m p l y f r o m d e u t e r i oc h l o r o f o r m and m o n o d e u t e r i o -e t h a n o l . The p r e v i o u s l y n o t d e s c r i b e d e t h o x y -[ H j m e t h y l e n e m a l o n o n i t r i l e c a n be p r e p a r e d f r o m t h e d e u t e r a t e d o r t h o e s t e r and dideuterio-malononitrile. R i n g c l o s u r e w i t h a c e t a m i d i n e i n e t h a n o l y i e l d s 4-amino-5-cyano-2-methyl-1 6 -H l p y r i m i d i n e w i t h o u t any l o s s o f d e u t e r i u m l a b e l .

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