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Shh pathway impairment in neuronal precursor cells from the subventricular zone of the Ts65Dn mouse, an animal model for Down Syndrome

✍ Scribed by V.M. Mitrugno; S. Trazzi; R. Bartesaghi; E. Ciani


Book ID
116552239
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
70 KB
Volume
28
Category
Article
ISSN
0736-5748

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## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin