Sexually dimorphic interaction between the DRD1 and COMT genes in schizophrenia
✍ Scribed by Janet Hoenicka; Elena Garrido; Guillermo Ponce; Roberto Rodríguez-Jiménez; Isabel Martínez; Gabriel Rubio; Miguel Ángel Jiménez-Arriero; Tomás Palomo
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 141 KB
- Volume
- 9999B
- Category
- Article
- ISSN
- 1552-4841
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## Abstract Several lines of evidence suggest that psychosis is associated with altered dopaminergic neurotransmission. Dopamine is catabolized by monoamine oxidase (MAO) and catechol‐O‐methyl transferase (COMT). We hypothesized that the genes encoding MAOA and COMT might contain genetic variation
A possible dysregulation of dopaminergic neurotransmission has been implicated in a variety of neuropsychiatric diseases. In the present study we systematically searched for the presence of mutations in the 5'flanking region of the dopamine D1 receptor (DRD1) gene. This region has previously been sh