Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder

Analysis of a novel functional polymorph

Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia

✍ de Oliveira, Jo�o R. Mendes; Otto, Paulo A.; Vallada, Homero; Lauriano, Val�ria; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 11 KB 👁 2 views

It has been suggested that the serotonin transporter (5-hydroxytryptamine-transporter or 5-HTT) may be involved in the pathogenesis of affective disorders. Recently, Collier et al. (1996) found that the frequency of the low-activity short variant (s) of the 5-HTT-linked polymorphic region (5-HTTLPR)