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Systematic screening for mutations in the 5′-regulatory region of the human dopamine D1 receptor (DRD1) gene in patients with schizophrenia and bipolar affective disorder

✍ Scribed by Cichon, Sven; Nöthen, Markus M.; Stöber, Gerald; Schroers, Roland; Albus, Margot; Maier, Wolfgang; Rietschel, Marcella; Körner, Judith; Weigelt, Bettina; Franzek, Ernst; Wildenauer, Dieter; Fimmers, Rolf; Propping, Peter

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 489 KB
Volume: 67
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960726)67:4<424::aid-ajmg21>3.0.co;2-k

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✦ Synopsis

A possible dysregulation of dopaminergic neurotransmission has been implicated in a variety of neuropsychiatric diseases. In the present study we systematically searched for the presence of mutations in the 5'flanking region of the dopamine D1 receptor (DRD1) gene. This region has previously been shown to contain a functional promoter [Minowa et al.,

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Using single strand conformational analysis we screened the complete coding sequence of the serotonin 1F (5-HTIF) receptor gene for the presence of DNA sequence variation in a sample of 137 unrelated individuals including 45 schizophrenic patients, 46 bipolar patients, as well as 46 healthy controls